ESR1 and central nervous system cancer: Based on the observation that Connexin 43 expression in the testis, as well as in glioma cells, is under the control of estrogen/estrogen receptor signaling [57,58], one of the main pathways involved in the control of testicular activity [59,60], we decided to investigate any changes in the localization and expression of steroidogenic enzymes and estrogen receptors to clarify the possible endocrine-disrupting effect of glyphosate.