Pance et al. reported that ATP2B4 deletion fully inhibited PMCA4 expression but had a very slight effect on the parasite growth in human stem cell-derived erythroid cells [42], whereas Villegas-Mendez et al. demonstrated that ATP2B4 gene targeting did not alter parasitemia in mice infected by Plasmodium berghei but did protect mice by against cerebral malaria induced by Plasmodium berghei [41]. This evidence concerns the gene ATP2B4 and parasitic infectious disease.