BCL2 and diabetes mellitus: In addition, in the type 1 diabetes model, senescent β-cells contribute to the immune-mediated destruction process, and the removal of senescent β-cells through treatment with senolytic drugs (such as ABT-199 (Bcl-2 inhibitor) and ABT-737 (Bcl-2, Bcl-xL, Bcl-w inhibitor)), prevents the progression of diabetes in the NOD type 1 diabetes mouse model [77].