ADM and acute respiratory distress syndrome: In this context, mid-regional pro-adrenomedullin (MR-proADM) is an emerging marker of sepsis that plays a critical role in the regulation of vascular permeability and stabilization of microcirculation, in the response to tissue injury and in regulating leucocytes recruitment following tissue damage, which are key drivers of acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation and cardiovascular complications in COVID-19 [17,18].