Carrying out a weight-matched comparative assessment between obese adolescents with altered insulin sensitivity and obese insulin-sensitive control adolescents, the former exhibited fasting hyperglycemia and hyperinsulinemia, consequently associated with increased rates of HGP, impaired insulin-mediated suppression of lipolysis, and impaired insulin-mediated suppression of HGP [98]. The gene discussed is INS; the disease is Hyperglycemia.