Particularly, the innate immune response mainly regulates aseptic inflammation triggered by metabolic stress in the liver promoting the release of IL-1β and IL-18 and C-C chemokine ligand type 2 and type 5 (CCL2 and CCL5), together with C-C chemokine receptor type 2 and type 5 (CCR2 and CCR5), which, in turn, are able to induce hepatic cell injury and liver fibrosis by increasing immune cell aggregation and infiltration and amplifying the inflammatory response [157,158]. The gene discussed is CCR2; the disease is Hepatic fibrosis.