In this regard, Zusi et al. evaluated the association between NAFLD and eleven single-nucleotide polymorphisms (SNPs) at genetic loci potentially associated with liver damage (GCKR, MBOAT7, and GPR120); oxidative stress (SOD2); lipid metabolism (PNPLA3, TM6SF2, LPIN1, ELOVL2, FADS2, and MTTP); and fibrogenesis (KLF6) in a pediatric population. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.