As shown in the heatmap (Figure 2H), the estrogen-regulated genes Klf4, Bhlhe40, Elf3, Pmaip1, Celsr1, Sox9, Llgl2 and Dio2 were upregulated in HSD17B1TG vs. WT uterus and in the dataset from Xiang et al., 2019 [21], suggesting that these may be central genes in the estrogen-dependent adenomyosis development both in human and mouse. Here, DIO2 is linked to adenomyosis.