Although there was no statistically significant difference between the genotypes in circulating E2 concentration in any time point studied (Figure 5C), we tested the HSD17B1 dependence of the adenomyosis phenotype by treating the mice with an HSD17B1 inhibitor beta thiazole (compound no. 21 in Table 1 in Messinger et al., 2008 [24]). This evidence concerns the gene HSD17B1 and adenomyosis.