ADCYAP1R1 and optic neuritis: Most recently, a pioneering study employing conditional PAC1 KO mice with targeted deletion of the gene Adcyap1r1 in the retina elegantly demonstrated that gene ablation exacerbated axonal pathology and increased microglia polarisation in the retina of mice undergoing EAE, highlighting the retinoprotective role mediated by the receptor in an MS model of optic neuritis [154].