It is highly likely that an increasing number of patients will be diagnosed with oligometastatic PC due to advances in imaging, particularly with the increasing use of prostate specific membrane antigen (PSMA) positron emission tomography (PET) scans, which can detect disease recurrence at an earlier stage with lower prostate specific antigen (PSA) levels than conventional imaging (computed tomography and bone scintigraphy). This evidence concerns the gene FOLH1 and pachyonychia congenita.