For this purpose, we analysed the sensitivity of the panel of HIV-2 primary isolates to neutralization by HIV-2 V3 region (1.7A and 6.10F), CD4 bindings site (CD4bs) (6.10B) and CD4-induced (CD4i) (1.4H) epitope specific mAbs [11] during infection of co-receptor indicator GHOST (3) cell lines expressing either CCR5, CXCR4, GPR15 or CXCR6,. This evidence concerns the gene CD4 and infection.