Whereas the global knockout (KO) of GLUT4 in mice leads to impaired growth developmental and cardiac hypertrophy, muscle-specific KO of GLUT4 in mice (mG4KO) results in an insulin-resistant and mildly diabetic phenotype [35,36], highlighting the importance of skeletal muscle glucose disposal for whole-body glycaemia. Here, SLC2A4 is linked to cardiac hypertrophy.