SLC2A4 and Glucose intolerance: Consequently, combined knockout of GLUT4 in adipose tissue and skeletal muscle in mice (amG4KO) leads to fasting hyperglycemia, glucose intolerance, and an elevated risk to develop IR compared to both aG4KO and mG4KO, which emphasizes the key role of the adipose tissue-skeletal muscle connectivity in glucose homeostasis [39].