IRS1 and Wilson disease: The exact inverse relationship of p-IRS-1(Ser616) levels with WD intake were observed in wild-type C57BL/6J mice, where we observed a significant increase in p-IRS-1(Ser616) levels in the entorhinal cortex of 8M WD and 12M WD animals compared to age-matched controls and the youngest 4-month-old animals.