The data presented in Figure 6A show that, in the wild-type model, without genome-wide alterations, WD induces insulin resistance, whereas in the AD model, WD has a downregulatory effect on p-IRS-1(Ser616) levels, suggesting a protective role for the transgene, Swedish double mutation (K670N, M671L) in APP gene. The gene discussed is IRS1; the disease is Alzheimer disease.