INS and Alzheimer disease: In contrast, when analyzing p-Tau(Thr231) levels, we observed no effect of WD-dependent insulin resistance in wild-type C57BL/6J strain mice, and in the entorhinal cortex of AD Tg2576 mice, there was an increase in p-Tau(Thr231) levels with age, following integration of the transgene in a manner independent of insulin signaling.