Given the HOX gene widespread reactivation and their functional role in glioma and GSC [7,8,9], it can be hypothesized that HOXA-AS2 collaborates with some of them in this process, such as the lncRNA HOTAIRM1 that is overexpressed in both IDHwt samples and GSCs, such as HOXA-AS2. This evidence concerns the gene HOTAIRM1 and glioma.