NOS2 and Alzheimer disease: miR-326 decreased Aβ and Tau tangle formation, attenuated apoptosis, improved cell viability, and downregulated stress proteins in AD [228,229]; sustained axon development and regulated neuron death via BDNF1 and HIF1 in ALS [230]; inhibited iNOS activation and suppressed DA neuron apoptosis in PD [231,232]; and induced Th17 differentiation and maturation in MS [233].