Meanwhile, the other family member of miR-29 (miR-29c) not only directly regulated BACE1 expression in HEK-293 cell lines and in the APPswe/PSΔE9 mice [68], but also targeted the neuron navigator 3 (an axon guidance regulator) in the same transgenic AD mouse model [66]. This evidence concerns the gene BACE1 and Alzheimer disease.