The miR-140-5p involvement in AD included mitochondrial dysfunction, autophagy, Aβ, and Tau accumulation and free radical production [180,213], whereas miR-140-5p dysregulation in HD was involved in excitatory synapse function, in increased postsynaptic proteolysis, and in electrophysiological alterations due to ADAM10 hyperactivity [177]. This evidence concerns the gene MAPT and Alzheimer disease.