LEP and LEPR gene mutation signatures involved in colon cancer are mainly missense, frameshift, silent, nonsense, and splice site mutations (LEP: g8r, p23l; LEPR: x14_splice d124y, g179afs*35 v198a, s256y s303s, x429_splice l1094f, v430i s541p, w558* r573h, s595s l598p, v606v r612c, i814l i845t, v846v d921y, s927s q1034h, k1074t s1090r) [87]. This evidence concerns the gene LEPR and colonic neoplasm.