LEP and obesity due to melanocortin 4 receptor deficiency: Specifically, it mediates the inflammatory response in obesity via adipocyte-secreted molecules, i.e., hormones (the most relevant being adiponectin, leptin, resistin, and ghrelin), growth factors, and proinflammatory cytokines, interfering in CRC pathogenesis through cell growth, proliferation, angiogenesis, and expression processes.