LEP and obesity due to melanocortin 4 receptor deficiency: The LEP A19G polymorphism (rs2167270) consisting of an A→G transition at nucleotide 19 in the exon 1 5′-untranslated region (Hager et al., 1998) was found to be associated with obesity in various cases [92,100,101], whereas a link was not found in [102].