As an adipokine, leptin seems to have a direct association with proliferation and apoptosis processes in CRC at various levels via the PI3K/AKT/mTOR signaling pathway, as well as with the improved expression of VEGF and VEGF-R2 via the PI3K, JAK2/STAT3, and ERK1/2 signaling pathways, as supported by in vitro, in vivo, and translational studies. Here, LEP is linked to colorectal carcinoma.