LEP and obesity due to melanocortin 4 receptor deficiency: Moreover, various polymorphisms in the LEP gene are linked to extreme obesity, such as D7S514, D7S680, D7S530 [90], D7S504, and D7S1875 [91], while the most frequently studied LEP SNPs are rs7799039 [92], rs2167270 [93], rs4731426, rs2071045 [94], and rs17151919 [95] as determinants in obesity [96].