LEP and obesity due to melanocortin 4 receptor deficiency: A common LEP G2548A polymorphism (rs7799039) consisting of a G→A transition at nucleotide −2548 upstream of the ATG start codon in the 5′ promoter was also associated with obesity or body weight gain in various cases [93,100,103,104,105], whereas other reports failed to prove such an association [106,107,108,109].