Germline PVs in MMR genes predispose to Lynch syndrome, which is characterized by a higher risk of developing non-polyposis-associated colorectal cancer (HNPCC) as well as extracolonic neoplasms, including pancreatic cancer and prostate cancer [77], whereas microsatellite instability (MSI) due to somatic impairment of MMR can be found in sporadic colorectal cancer. This evidence concerns the gene MRC1 and prostate cancer.