PALB2 and familial pancreatic carcinoma: Based on the available literature, it is estimated that 17 to 25% of pancreatic cancer harbor somatic PVs in one of the genes involved in DDR, mainly those implicated in homologous recombination DNA damage response and repair (HR), such as BRCA1, BRCA2, ATM, PALB2, ATRX, and RAD51 [36,37,38,39,40,41,42,43,44].