For example, some studies have shown that expression of the constitutively active form of Notch1 has an inhibitory effect on hepatocellular carcinoma cells and that blocking Notch with a γ-secretase inhibitor (GSI) in mice promotes the progression of hepatocellular carcinoma, suggesting that Notch operates as a tumor suppressor [14,15]. Here, NOTCH1 is linked to hepatocellular carcinoma.