Rehydragel® (Al(OH)3@heparanase, LV@HPA) was coated with polyethyleneimine (PEI) to synthesize LV@HPA/PEI nanoadjuvant. Then, OVA or tumour-derived autophagosomes (DRibbles) were adsorbed on the nanoadjuvant.The vaccine was formulated using LV@HPA/PEI-DRibble-DCs. The nanoformulation was used for vaccination ‡. The gene discussed is HPSE; the disease is neoplasm.