Cell viability was ~100% at concentrations up to 10 μg/mL. The NP promoted OVA uptake by the DCs (free OVA uptake: 7% vs. LV@HPA/PEI-OVA: 25.5%), DC maturation, and cross-presentation of OVA. The NP increased secretion of IFN-γ by CTLs isolated from tumour-bearing mice. No obvious body weight loss or abnormality were noticed in the immunized mice during the study course (54 days). Vaccination supressed tumour growth and prolonged mouse survival. Here, IFNG is linked to neoplasm.