In rodent models of cardiac pressure overload or myocardial infarction, the three NOS isoforms (NOS1, NOS2, and NOS3) may play neutral, protective, or even detrimental roles in myocardial remodeling, depending on the NOS activity, the cellular and even subcellular location of each NOS and their regulators [25,47]. Here, NOS3 is linked to myocardial infarction.