This included the mRNA surveillance pathway, but also pathways related to hormonal control and metabolism, including oestrogen signalling pathway; GnRH secretion and GnRH signalling pathway; parathyroid hormone synthesis, secretion, and action; growth hormone synthesis, secretion, and action; mineral absorption; renin secretion; bile secretion; amino sugar and nucleotide sugar metabolism; fatty acid degradation and fatty acid metabolism; insulin signalling pathway; alcoholism; Cushing’s syndrome; purine metabolism; and histidine metabolism. The gene discussed is GNRH1; the disease is alcohol dependence.