Several KEGG pathways were identified as specific to the total EV proteome of normoxic animals, including phagosome and carbon metabolism, ferroptosis, proteoglycan in cancer, proximal tubule bicarbonate reclamation, glycolysis/gluconeogenesis, thyroid hormone synthesis, and HIF-1 signalling pathway, whereas no KEGG pathways were specific to the hypoxia EV proteome only. Here, HIF1A is linked to cancer.