In another study, the brain-impermeable FAAH inhibitor URB937 was effective at reducing acute and chronic trigeminal hyperalgesia induced by nitroglycerin, suggesting that an increase in AEA levels and activation of CB1 receptors in peripheral nerves and tissues may reduce migraine pain and produce fewer side effects as compared with those acting in the CNS [68,70]. The gene discussed is FAAH; the disease is migraine disorder.