ERBB2 and neoplasm: Consequently, in tissues in which the p53 pathway is suppressed, such as tumor tissue, miR-125b would suppress proliferation by down-regulating erbB2/3 and E2F3, however, in tissues with intact p53 pathways, such as endometriosis tissue, miR-125b suppression of p53 pathways would be pro-tumorigenic.