Therefore, not surprisingly, when these two AKT modulating miRNAs were overexpressed through mimics in 3 childhood ALL cell lines, lymphoblasts exhibited decreased proliferation and enhanced apoptosis in response to dexamethasone (likely due to the downregulation of the antiapoptotic BCL-2 family member Mcl1) [70]. The gene discussed is BCL2; the disease is acute lymphoblastic leukemia.