Interestingly, ectopic expression of these 2 miRNAs could resensitise cells to dexamethasone in the B-ALL cell line RS4;11 (and in the childhood B-ALL SEM cell line, too) and to etoposide, likely through the downregulation of the driver MLL-AF4 and the cell cycle regulator CDKN1b [39]. The gene discussed is CDKN1B; the disease is acute lymphoblastic leukemia.