AFF1 and acute lymphoblastic leukemia: Interestingly, ectopic expression of these 2 miRNAs could resensitise cells to dexamethasone in the B-ALL cell line RS4;11 (and in the childhood B-ALL SEM cell line, too) and to etoposide, likely through the downregulation of the driver MLL-AF4 and the cell cycle regulator CDKN1b [39].