BRCA1 and Alzheimer disease: Given the essential role of BRCA1 in the HR-mediated DSB repair [205] and exploitation of this pathway by NPCs toward neuronal plasticity related to cognitive functions [206], the BRCA1 pathology seems more relevant to the hippocampal and entorhinal cortex neurons as well as migratory NPCs from the subventricular zone in the AD and dementia.