ATP2A1 and Brody myopathy: Interestingly, besides the association of primary pathogenic genetic variants in the ATP2A1 gene with Brody myopathy (OMIM#601003, a rare autosomal recessive disorder characterized by painless muscle cramping and exercise-induced impaired muscle relaxation) [43], other conditions linked with aging, neurodegeneration, and muscular dystrophy also depress ATP2A1 function with the potential to impair intracellular calcium homeostasis and contribute to muscle atrophy and weakness [42].