ADRB2 and melanoma: β-adrenergic receptors (β-AR), which belong to the guanine nucleotide-binding G protein-coupled receptor superfamily, are expressed in human tissues, such as benign melanocytic naevi, atypical naevi and malignant melanoma, as well as in B16F10 melanoma, the most frequently used syngeneic murine melanoma, as evidenced by qPCR, Western blot and cytofluorimetric analyses [2,3,4,5], and have emerged as important mediators of catecholamine effects on melanoma growth.