Likewise, in B-cell malignancies, proto-oncogenes are often translocated to the locus of the immunoglobulin heavy chain (IGH) [3], such as MYC in Burkitt lymphoma (IGH/MYC), CCND1 in mantle cell lymphoma, BCL-6 in diffuse large B-cell lymphoma (DLBCL) and BCL-2 in follicular lymphoma [4]. The gene discussed is CCND1; the disease is diffuse large B-cell lymphoma.