Amelioration of the DM1-like phenotype by increasing MBNL1 expression was also obtained with miRNA sponge constructs and antagomiRs (cholesterol-2′OMe-ASOs) specific to microRNAs targeting the 3′ UTR of MBNL1/2 mRNAs in a Drosophila model of DM1 and in the HSALR mouse model, respectively [115,116,140,141]. Here, MBNL1 is linked to myotonic dystrophy type 1.