One of the histopathological hallmarks of PD is an aggregation of misfolded, insoluble α-synuclein, which has the ability to form Lewy bodies, and the development of abnormal Lewy neurites in diseased neurons, which contain abnormal α-synuclein filaments similar to those found in Lewy bodies, which promote neurodegeneration [75]. This evidence concerns the gene SNCA and Parkinson disease.