More recently, an orphan member of the adhesion G-protein-coupled receptor family, EGF, latrophilin, and seven transmembrane domain-containing protein 1 (ELTD1) was reported to be upregulated in high-grade glioma blood vessels, and its expression has been associated with glioma progression and has also been suggested as a potential therapeutic target in glioblastoma [89,90,91,92]. Here, ADGRL4 is linked to central nervous system cancer.