Among the many receptors expressed by the GSCs, integrin-1 and tropomyosin receptor kinase type A (TRKA) can bind to the connective tissue growth factor (CTGF) released by the astrocytes, and produce zinc finger E-box binding homeobox-1 (ZEB1), leading to tumor cell infiltration [110,111]. The gene discussed is ZEB1; the disease is neoplasm.