SHH and glioblastoma: They suggested a potential axis between the SHH signaling pathway and CX43 at least on two aspects: “permissive”, in which SHH-GLI signaling favors the intercellular communication and patterning, leading to microenvironmental changes and tumorigenic onset, and “supporting” the GBM stemness signature so that the aberrant SHH-GLI pathway promotes GSC population [152].