Stress programs in tumor cells are based on a lot of universal signaling pathways, including the omnipresent activation of TGF-β1 and TNF signaling, as well as the activation of key TFs (NF-κB, STAT, HIF, AP-1, p53, STAT), and protein kinases (mTOR, MAPK, PI3K, AMPK) [110,202,203,204,205,206,207]. Here, SOAT1 is linked to neoplasm.