A growing amount of evidence suggest that, in addition to biochemical processes, hyperglycemia can also induce epigenetic modifications that lead to increased oxidative stress, PKC signaling, AGE formation, NFkB-dependent monocyte-chemotactic protein 1 (MCP-1) and VCAM1 expression, with consequent endothelial dysfunction and atherosclerosis [9]. This evidence concerns the gene PRRT2 and Hyperglycemia.