Epigenetic changes in the promoter of NF-κB subunit p65 (increased H3K4m1 by the histone methyltransferase Set7) in aortic endothelial cells induced by transient hyperglycemia (16 h) persist for at least 6 days of subsequent normal glycemia, as do NF-κB-induced increases in MCP-1 and VCAM-1 expression [65]. Here, NFKB1 is linked to Hyperglycemia.