SOD2 and type 2 diabetes mellitus: The main genes whose variants are commonly associated with both T2DM and CVD are involved in LDL oxidation (paraxonase, polymorphism Gln-Arg 192 [28] or Met-Leu 54 [29], which lead to decreased levels or activity of paraxonase, an enzyme that normally protects LDL from proatherogenic modifications), redox balance (superoxide dismutase 2 and polymorphism Ala-Val 16, which lead to decreased SOD2 activity) [30], the adiponectin pathway (adiponectin, polymorphism +276 G/T [31] and adiponectin receptor ADIPOR1, haplotypes rs7539542, rs10920531 and rs4950894 [32].