Hyperacetylation of histone H3 at lysine residues 9 and 14 (H3K9/K14) coexisting with DNA hypomethylation of CpG islands was observed in response to hyperglycemia in human vascular cells on multiple gene promoters, including heme oxygenase 1 (HMOX1), IL-8, matrix metalloproteinase 1 (MMP1) and 10 (MMP10) and cysteine/glutamate transporter (SCL7A11) [59]. This evidence concerns the gene MMP1 and Hyperglycemia.