RELA and Hyperglycemia: Hyperglycemia activates the NFκB-p65 gene in endothelial cells also by mono-methylation of lysine 4 on histone 3 (H3K4m1) through histone methyltransferase Set7 and demethylation of H3K9 on the p65 promoter by lysine-specific demethylase 1 [55].