LHCGR and Infertility: Inactivating mutations in a number of these GPCRs have been shown to result in intracellular retention and infertility, including the LH receptor (LHCGR/LHR), FSH receptor (FSHR), and GnRHR, with all three being amenable to pharmacological chaperone rescue and restoration of signalling [13,14,15].