LDLR and atherosclerosis: It is important to note that in the above-referenced study, aortic arches from diabetic mice devoid of the Ldlr were also transplanted into diabetic wild-type or Diaph1 null mice [65]; compared to wild-type diabetic recipient mice, deletion of recipient Diaph1 significantly accelerated regression of atherosclerosis, as lesion area and lesional macrophage content were significantly reduced by Diaph1 deletion in the recipient mice.