AGER and infection: Although in a range of experiments testing the RAGE pathway in induced infections, including bacteria, viruses, and parasites [114,115,116,117] and, most recently, SARS-CoV-2 [118], salutary and non-detrimental effects were noted upon genetic Ager deletion or pharmacological antagonism of RAGE, these experiments were conducted under controlled conditions and most often in healthy, young mice.