Using rodent models of infection, Zhou and colleagues showed that camostat protects mice from SARS-CoV-induced mortality, and Iwata-Yoshikawa and colleagues showed that SARS-CoV- or MERS-CoV-infected TMPRSS2-deficient mice exhibit reduced viral replication mirrored by a less severe lung pathology and inflammatory response [111,112]. The gene discussed is TMPRSS2; the disease is infection.