Research undertaken by Obexer et al. [100] and Hagenbuchner et al. [101] demonstrated that intramitochondrial accumulation of ROS in human neuroblastoma cells contributes to the fusion of FOXO3 with the BIM protein, which, in turn, evokes mPTP opening and subsequently cytochrome c leakage. The gene discussed is BCL2L11; the disease is neuroblastoma.