Indeed, CDDO-Me induces autophagy, apoptosis and endoplasmic reticulum (ER) stress with the increased ERK1/2 activity and the suppression of AKT/mTOR signaling pathway in human chronic myeloid leukemia K562 cells [70]. This evidence concerns the gene AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive.