In addition, myriad genes have been expounded to partake in the ALP, for instance, SNCA, DJ-1, GBA, LRRK2, PINK1, transmembrane protein 175 (TMEM175), cathepsin B (CTSB), cathepsin D (CTSD), sphingomyelin phosphodiesterase 1 (SMPD1); however, mutations in these genes can culminate in the dysfunctioning of the ALP, and finally contributes to PD evolution [79,81,82,83]. This evidence concerns the gene SMPD1 and Parkinson disease.