In addition, it has been recently discovered that therapy with the aid of ghrelin contributed to a substantial escalation in the amount/number of neural stem cells (NSCs) of the midbrain, facilitated in vitro as well as ex vivo DArgic nerve cell differentiation via the canonical Wnt signaling pathway, and thereupon renders the prospect that subjection to ghrelin may be a newfangled, effective, and propitious strategy for PD therapy [147]. This evidence concerns the gene GHRL and Parkinson disease.