SNCA and Parkinson disease: According to another investigation, the preformed fibrils (PFF) might disseminate in in vitro nerve cell culture in a “prion-like” fashion, and when administered directly inside the brain of a mouse by means of injection, they might disseminate in vivo in a similar fashion, culminating in the generation of pSer129-α-synuclein-positive LBs-like clumps, and eventually contribute to the emergence of PD [107].