PSEN1 and early-onset autosomal dominant Alzheimer disease: Interestingly, MBG also downregulated the genes involved in the Alzheimer’s disease (AD) genomic profile in DSS rats, i.e., APP mRNA expression was almost two times lower, and PSEN-1 mRNA was 40% lower in DSS-MBG vs. DSS-LS rats (Table 5).