CREB1 and Cognitive impairment: In patients with mild cognitive impairment, loss of SIRT1 upregulated miR-134 expression, which inhibited CREB expression and reduced BDNF transcription mediated by the formation of a transcription complex containing CREB and its coactivators CREB-binding protein (CBP) and P300 [109,110], thus eventually resulting in impaired synaptic plasticity.