TRPC6 and esophageal squamous cell carcinoma: For instance, the expression levels of TRPC6 mRNA and protein are higher in ESCC tissue compared to normal esophageal tissue, and the inhibition of TRPC6 channel activity in human ESCC cells suppresses cell proliferation and induces G2/M phase arrest, as well as decreases tumor formation in a mouse xenograft model [53].