TRPA1 and gastroesophageal reflux disease: Although upregulation of mucosal TRPA1 channel expression was shown to mediate macroscopic and microscopic gastric mucosal injury in a rat model of gastritis [38], there is no current evidence to support a role for esophageal epithelial TRPA1 channel in mediating esophagitis or esophageal hypersensitivity in gastroesophageal reflux disease (GERD) patients.