Although recent studies reported that altered expression of at least two different ion transporters, anoctamin 1 (ANO1) and sodium-hydrogen exchanger member 3 (NHE3), could contribute to EoE pathogenesis [3], none of the mucosal TRP channels are thought to play a role in the condition and, thus, further investigation is needed to explore their possible role in EoE. The gene discussed is SLC9A3; the disease is eosinophilic esophagitis.