Further studies are needed to explore the exact role of the TRPV4 channel and its downstream pathways in esophageal barrier integrity, submucosal gland secretion, NERD, GERD, Barrett’s esophagus, and esophageal tumors, since targeting this channel using currently available agonists and antagonists could provide promising therapeutic options for these conditions. The gene discussed is TRPV4; the disease is esophageal adenocarcinoma.