The finding that dysregulation of TRPC6, TRPM2, TRPM7, TRPM8, TRPV1, TRPV2, and TRPV6 channel expression was linked to ESCC pathogenesis and prognosis suggests that these TRP family members could be used as prognostic markers and would be promising therapeutic targets [52]. This evidence concerns the gene TRPM2 and esophageal squamous cell carcinoma.