Considering a series of 30 TBSCCs, Morita et al. [19] discovered that both p53 and EGFR nuclear and membranous immunohistochemical expression in neoplastic cells was significantly associated with T classification, whereas EGFR expression alone was significantly more frequent in patients with lymph node metastasis compared to those without node involvement. This evidence concerns the gene TP53 and metastatic malignant neoplasm in the lymph nodes.