In vitro analyses confirmed the complex formation between emmprin and CD73, the more abundant production of MMP-2 coming from fibroblasts co-cultured with TBSCC cells than from those cultured alone, and the reduction in MMP-2 production by the transfection of CD73 siRNA into fibroblasts co-cultured with tumor cells [15]. This evidence concerns the gene MMP2 and neoplasm.