Human maspin (mammary serine protease inhibitor), identified originally in normal mammary epithelia, is encoded by SERPINB5, located on the long arm of chromosome 18 (18q21.3); it has a multitude of functions, which include modulating cancer cell motility and invasiveness, apoptosis, angiogenesis, and adhesion [41,42]. The gene discussed is SERPINB5; the disease is cancer.