Localization of the TRPA1 channel in different cell types of the gastrointestinal tract (extrinsic and enteric neurons, neuroendocrine, and immune cells) and its similar regulation in human and mouse inflammation suggest important channel functions in IBD that, however, need further investigation before the proposal of its potential therapeutic value in these disorders of the gastrointestinal tract. Here, TRPA1 is linked to irritable bowel syndrome.