In these experiments, we observed an accumulation of DDIT3 in conjunctival epithelial cells from pathological specimens compared to the control (Figure 1b and Supplementary Figure S1), indicating that severe ER stress and epithelial damage at the ocular surface of Sjögren’s syndrome patients is associated with the activation of the DDIT3 signaling pathway. This evidence concerns the gene DDIT3 and Sjogren syndrome.