ACHE and status epilepticus: The canonical mechanism of the neurotoxicity of OPs is AChE inhibition [123]; thus, acute AChE inhibition (>60 to 80%) can induce a clinical condition termed cholinergic crisis [47], which is characterized by peripheral parasympathetic symptoms, the depression of central breathing control, seizures that can quickly progress to status epilepticus (SE), and the death of the intoxicated individual [124,125].