Moreover, the involvement of M1-like and M2-like macrophages in the pathogenesis of RA is associated with their regulation of specific signaling pathways (c-Jun N-terminal kinase (JNK), IκB kinase alpha (IKKα), Notch signaling pathway) and with the activation of NF-κB [46]. Here, NFKB1 is linked to rheumatoid arthritis.