CXCR4 and amyotrophic lateral sclerosis: Several scientific works have reportedan increase in circulating chemokines and cytokines in ALS patients, as recently detailed by Liu et al. [46], and the upregulation of chemokine receptors CXCR3, CXCR4, and CCR2 wasalso highlighted in the pathology of interest by Perner et al. [47], whoalso proposed CXCR3 and its ligands as possible therapeutic targets for ALS.