WEE1 and amyotrophic lateral sclerosis: Even if some effort has been directed toward trying to highlight the role of protein kinases in ALS progression, this has not been recently orextensively done with respect toG-protein coupled receptors, biological actors which have been demonstrated to be detrimental to neuronal and physiological conditions.It is important to remember that ALS is a non-cell-autonomous disease, which means that the neuronal damage characterizing the pathology is caused by aberrant processes also happening outside the neurons themselves.