In addition to this, Bilsland et al. reported that the knock-out of CB1 receptors in SOD1G39A ALS-affected mice had no appreciable effect on disease onset [136], and regarding this, Shoemaker et al. reportedthat the activation of CB1 could exacerbate disease progression [80]. The gene discussed is CNR1; the disease is amyotrophic lateral sclerosis.