In the same animal model, Rossi et al. reported an interaction between intravitreal RvD1 and local endogenous sirtuin-1 (SIRT1) [42], a protein with nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase activity, whose dysregulation has been linked to several retinal diseases [43]. Here, SIRT1 is linked to Abnormal retinal morphology.