ANXA2 and ischemia: This evidence was also supported by the results obtained in a mouse model of ischemia-induced retinal neovascularization, in RPE cells silenced for AnxA2 and exposed to photocoagulation and in a rat model of argon laser coagulation-induced CNV, in which AnxA2 emerged as an inducer of the VEGF-VEGF receptor 2 (VEGFR2) pathway [67,68].