It was found that transcription factor adaptor protein complex 4 (AP-4) induced overproduction of Gal-1 under hyperglycemia; OTX008 blocks the activation of the Akt serine threonine kinase pathway and prevents the accumulation of Gal-1 [79], suggesting a novel role as a Gal-1 inhibitor and a possible therapeutic target to treat fibrosis in diabetes complications. This evidence concerns the gene MARK2 and Hyperglycemia.