These exosomes are taken up by tumor-associated macrophages (TAMs), and exosomes containing miRs downregulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/v-akt murine thymoma viral oncogene homolog (AKT), suppressor of cytokine signaling (SOCS)1/signal transducer and activator of transcription (STAT)1 (Figure 2). Here, PTEN is linked to neoplasm.