Similarly, in HCC, tumor-derived exosomes deliver miR-1247-3p to fibroblasts and reprogram them to cancer-associated fibroblasts (CAFs) in the lung pre-metastatic niche by directly targeting beta-1,4-galactosyltransferase 3, that provokes β1-integrin-NF-κB signaling [42]. Here, NFKB1 is linked to neoplasm.