RNF213 and famililal cerebral cavernous malformations: Several previous studies have shown that RNF213 may also be involved in other vascular phenotypes, such as premature coronary artery disease, renal or aortic artery disease [70], hypertension [71], cerebral cavernous malformation [72], fibromuscular dysplasia [73], stenosis/major intracranial artery occlusion [74] and intracranial aneurysm [75].