Its global expression is strongly increased in cancer cells and NCL has been proposed as a tumor marker for cancers from many histological origins, such as cervical carcinoma, pediatric intracranial ependymoma, pancreatic ductal adenocarcinoma, glioma, gastric, hepatocellular, lung, colorectal, and endometrial carcinoma [15,17,34,38,39,40,41,42,43,44]. This evidence concerns the gene NUCLEOLIN and cancer.